Route near Barangay 589

Santa Mesa is a district in Manila, Philippines. It is surrounded by Pasig River on the southwestern side, and by the San Juan River on its southern and eastern side. Land borders include the districts of San Miguel to the west and Sampaloc to the north; and to the northeast is Quezon City.Santa Mesa was formerly a part of the Sampaloc district, from which it was partitioned and separated after it had its own parish in 1911.

Our Lady of Lourdes Hospital (abbreviated as OLLH) is a private non-profit tertiary hospital with 230-bed capacity located in Santa Mesa, Manila, in the Philippines. It is a part of the East Manila Hospital Managers Corporation, a subsidiary of Metro Pacific Investments Corporation. Our Lady of Lourdes Hospital was founded in 1958 by the Missionary Sisters Servants of the Holy Spirit congregation through Our Lady of Lourdes Hospital Inc., a non-stock, non-profit corporation.

Victorino Mapa Street, also known by its short form V. Mapa Street, is the main north–south road in the district of Santa Mesa in Manila, Philippines. The street, including its eastern extension, runs for 1.6 kilometers (0.99 mi) from the junction with Magsaysay Boulevard in the north to Pat Antonio Street in the southeast by the San Juan River that serves as the district's border with San Juan and Mandaluyong.

The Philippine Chung Hua School (PCHS) is located at 3217 Reposo Street, Santa Mesa, Manila, Philippines. The school teaches Chinese and Filipino, as well as English.