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Effingham is a city in and the county seat of Effingham County, Illinois, United States. It is in South Central Illinois. Its population was 12,511 at the 2019 census estimate. The city is part of the Effingham, IL Micropolitan Statistical Area. Effingham is home to a 198-foot-tall cross, The Cross at the Crossroads.

Effingham is an Amtrak intercity train station in Effingham, Illinois, United States . The station contains three houses, at the CSXT St. Louis Line Subdivision (ex-Pennsylvania Railroad) crossing that once served Amtrak's former National Limited line between Kansas City and either Washington D.C. or New York City until 1979.

St. Anthony of Padua High School is a private, Roman Catholic high school in Effingham, Illinois. It is located in the Roman Catholic Diocese of Springfield in Illinois. St. Anthony was established in 1874 by the School Sisters of Notre Dame. It is the only Catholic high school in a 50-mile radius.

The Effingham County Cultural Center and Museum is a historic building and museum located in Effingham, the county seat of Effingham County, Illinois. Built in 1871, the building was originally the Effingham County Courthouse.The courthouse was started in 1870 and completed in 1871 at a cost of roughly $30,000.