Route near Downtown

Atlanta's first Union Station, also known as Union Depot (1853–1864) was the original depot of Atlanta, Georgia. It was designed by architect Edward A. Vincent. It stood in the middle of State Square, the city's main square at the time, where Wall Street now is between Pryor Street and Central Avenue.

Atlanta's second Union Station was built in 1871 on the site of the 1853 station, burned in mid November 1864 when Federal forces left Atlanta for the March to the Sea. It was built in Second Empire style, designed by architect Max Corput. It was located at what is now Wall Street between Pryor Street and Central Avenue.

25 Park Place, formerly known as Trust Company of Georgia Building and later the SunTrust Bank Building is a 115 m (377 ft) 28-story skyscraper in Downtown Atlanta. Built across from Woodruff Park, construction was finished in 1971. It was once the headquarters for Trust Company of Georgia, which is now known as SunTrust.

The Atlanta Zero Mile Post is a stone marker which marked the terminus of the Western and Atlantic Railroad in Atlanta. It was located in a disused building in Downtown Atlanta, within the Underground Atlanta Historic District, under the Central Ave. viaduct, between Alabama and Wall streets. The Zero Mile Post was recognized with a historical marker by the Georgia Historical Commission in 1958 and entered into the National Register of Historic Places in 1977.

The Atlanta Hotel also known as Thompson's Hotel, was one of the original hotels in antebellum Atlanta, Georgia. It stood at the northwest side of State Square, pre-war Atlanta's central square, on the northwest side of Pryor Street between Decatur Street (then Marietta Street) and what is now Wall Street (which before the war was the railroad track).

The Byrdine F. Lewis College of Nursing and Health Professions contains the nursing school and school of allied health professions at Georgia State University.

The Georgia State University College of Law is a law school located in downtown Atlanta, Georgia. Founded in 1982, it is accredited by the American Bar Association and is a member of the Association of American Law Schools.In addition to the Juris Doctor degree, the college offers joint degree programs with other colleges at Georgia State University.

Murrell's Row was a red-light district of Atlanta "starting at the juncture of Line, Decatur and Peachtree streets" (i.e. at today's Five Points "and running back towards Pryor on Decatur street". According to Archival Atlanta:Named for the notorious Tennessee murderer, John A. Murrell, this section of town was a favorite hangout for thieves, gamblers, cutthroats, and prostitutes.

The Republic Block (completed in 1873) was at the time of its completion one of the most remarkable commercial constructions in Atlanta. It faced Pryor Street between Decatur St. and Railroad Ave. (now Wall St.), now site of Georgia State University buildings. It faced the Kimball House which stood across Pryor St.

The Trout House was one of three hotels in antebellum Atlanta, Georgia, along with the Atlanta Hotel and Washington Hall. It was built in 1849 by John F. Trout. It was a four-story brick building at the southwest corner of Decatur and Pryor Streets, facing the union depot and State Square.Confederate President Jefferson Davis spoke here during his visit to Atlanta of February 16, 1861, although he did not spend the night.