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The University of Pennsylvania Museum of Archaeology and Anthropology—commonly called the Penn Museum—is an archaeology and anthropology museum that is part of the University of Pennsylvania. It is located on Penn's campus in the University City neighborhood of Philadelphia.

The Children's Hospital of Philadelphia (CHOP) is a children's hospital in Philadelphia, Pennsylvania, with its primary campus located in the University City neighborhood of West Philadelphia next to the campus of the University of Pennsylvania. It is one of the largest and oldest children's hospitals in the world, and United States' first hospital dedicated to the healthcare of children.

College Hall is the oldest building on the West Philadelphia campus of the University of Pennsylvania. Prior to its construction, the university was located on Ninth Street in Center City, Philadelphia. The building was designed by Thomas Webb Richards and completed in 1873. The characteristic green color of the building is due to its composition of green serpentine stone.

The College and Academy of Philadelphia was a secondary school and later university located in Philadelphia. It was founded in 1749 by a group of local notables that included Benjamin Franklin and initially included a "charity school" that taught reading, writing, and arithmetic and a secondary school, the Academy, offering a more advanced curriculum.

The University of Pennsylvania School of Nursing (more commonly referred to as Penn Nursing) is an undergraduate and graduate institution at the University of Pennsylvania located in Philadelphia, Pennsylvania. According to U.S. News & World Report, the School of Nursing at Penn is among the top-ranked graduate nursing schools in the United States.

The Joseph H. Lauder Institute of Management & International Studies (The Lauder Institute) offers a joint degree program at the University of Pennsylvania, combining an MA in International Studies from the School of Arts & Sciences with an MBA from The Wharton School or JD from the Law School. Students pursue one of six Programs of Concentration focused on five regional areas (Africa, East and Southeast Asia, Europe, Latin America, or South Asia, the Middle East and North Africa) or the Global Program.

The Curtis Organ, named for publisher Cyrus H. K. Curtis, is one of the largest pipe organs in the world with 162 ranks and 10,731 pipes. It was manufactured by the Austin Organ Company as its Opus 1416 in 1926 for the Philadelphia Sesquicentennial Exposition. It was known as the "Organists' Organ" because the specifications were formulated by Henry S.

The Center for Applied Genomics is a Center of Emphasis at the Children's Hospital of Philadelphia with the primary goal of discovering and translating basic research findings into medical innovations.The Center is one of the world’s largest genetics research and analytical facilities. It is the primary center at a pediatric hospital with access to state-of-the-art high-throughput genotyping technology, and has processed genetic samples from over 100,000 people.

The Perelman School of Medicine, commonly known as Penn Med, is the medical school of the University of Pennsylvania. It is located in the University City section of Philadelphia. Founded in 1765, the Perelman School of Medicine is the oldest medical school in the United States and is one of the seven Ivy League medical schools.

The Ruth and Raymond Perelman Center for Advanced Medicine is a specialized medical facility located at 34th Street and Civic Center Boulevard, on the former site of the Philadelphia Civic Center, on the campus of the Hospital of the University of Pennsylvania. The $302-million project was designed by Rafael Viñoly Architects and completed in 2008.